Specific visualization of glioma cells in living low-grade tumor tissue.

ABSTRACT:

Background

The current therapy of malignant gliomas is based on surgical resection, radio-chemotherapy and chemotherapy. Recent retrospective case-series have highlighted the significance of the extent of resection as a prognostic factor predicting the course of the disease. Complete resection in low-grade gliomas that show no MRI-enhanced images are especially difficult. The aim in this study was to develop a robust, specific, new fluorescent probe for glioma cells that is easy to apply to live tumor biopsies and could identify tumor cells from normal brain cells at all levels of magnification.

Methodology/principal findings

In this investigation we employed brightly fluorescent, photostable quantum dots (QDs) to specifically target epidermal growth factor receptor (EGFR) t

SUBMITTER: Kantelhardt SR 

PROVIDER: S-EPMC2894859 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature