DDSolver: an add-in program for modeling and comparison of drug dissolution profiles.

ABSTRACT: In recent years, several mathematical models have been developed for analysis of drug dissolution data, and many different mathematical approaches have been proposed to assess the similarity between two drug dissolution profiles. However, until now, no computer program has been reported for simplifying the calculations involved in the modeling and comparison of dissolution profiles. The purposes of this article are: (1) to describe the development of a software program, called DDSolver, for facilitating the assessment of similarity between drug dissolution data; (2) to establish a model library for fitting dissolution data using a nonlinear optimization method; and (3) to provide a brief review of available approaches for comparing drug dissolution profiles. DDSolver is a freely available

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2895453 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature