Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic.

ABSTRACT: A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.

SUBMITTER: Kharel MK 

PROVIDER: S-EPMC2895501 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature