Nutrient control of eukaryote cell growth: a systems biology study in yeast.

ABSTRACT:

Background

To elucidate the biological processes affected by changes in growth rate and nutrient availability, we have performed a comprehensive analysis of the transcriptome, proteome and metabolome responses of chemostat cultures of the yeast, Saccharomyces cerevisiae, growing at a range of growth rates and in four different nutrient-limiting conditions.

Results

We find significant changes in expression for many genes in each of the four nutrient-limited conditions tested. We also observe several processes that respond differently to changes in growth rate and are specific to each nutrient-limiting condition. These include carbohydrate storage, mitochondrial function, ribosome synthesis, and phosphate transport. Integrating transcriptome data with proteome measurements all

SUBMITTER: Gutteridge A 

PROVIDER: S-EPMC2895586 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature