Controlling false discoveries in multidimensional directional decisions, with applications to gene expression data on ordered categories.

ABSTRACT: Microarray gene expression studies over ordered categories are routinely conducted to gain insights into biological functions of genes and the underlying biological processes. Some common experiments are time-course/dose-response experiments where a tissue or cell line is exposed to different doses and/or durations of time to a chemical. A goal of such studies is to identify gene expression patterns/profiles over the ordered categories. This problem can be formulated as a multiple testing problem where for each gene the null hypothesis of no difference between the successive mean gene expressions is tested and further directional decisions are made if it is rejected. Much of the existing multiple testing procedures are devised for controlling the usual false discovery rate (FDR) rather tha

SUBMITTER: Guo W 

PROVIDER: S-EPMC2895927 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature