Substance use and the treatment of resistant depression in adolescents.

ABSTRACT:

Objective

Despite the known association between substance use disorders and major depressive disorder (MDD) among adolescents, little is known regarding substance use among adolescents with MDD.

Method

Youths with MDD who had not improved after an adequate selective serotonin reuptake inhibitor trial (N = 334) were enrolled in the Treatment of SSRI-Resistant Depression in Adolescents trial. Analyses examined substance use (via the Drug Use Severity Index) and changes therein in relation to treatment and depressive symptoms. Adolescents meeting substance use disorder criteria via the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version at baseline were excluded.

Results

Substance use was common: 28.1% reported repeated

SUBMITTER: Goldstein BI 

PROVIDER: S-EPMC2895963 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature