Injured Fluoro-Jade-positive hippocampal neurons contain high levels of zinc after traumatic brain injury.

ABSTRACT: Hippocampal damage contributes to cognitive dysfunction after traumatic brain injury (TBI). We previously showed that Fluoro-Jade, a fluorescent stain that labels injured, degenerating brain neurons, quantifies the extent of hippocampal injury after experimental fluid percussion TBI in rats. Coincidentally, we observed that injured neurons in the rat hippocampus also stained with Newport Green, a fluorescent dye specific for free ionic zinc. Here, we show that, regardless of injury severity or therapeutic intervention, the post-TBI population of injured neurons in rat hippocampal subfields CA1, CA3 and dentate gyrus is indistinguishable, both in numbers and anatomical distribution, from the population of neurons containing high levels of zinc. Treatment with lamotrigine, which inhibits pre

SUBMITTER: Hellmich HL 

PROVIDER: S-EPMC2896019 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature