PCFamily: a web server for searching homologous protein complexes.

ABSTRACT: The proteins in a cell often assemble into complexes to carry out their functions and play an essential role of biological processes. The PCFamily server identifies template-based homologous protein complexes [called protein complex family (PCF)] and infers functional modules of the query proteins. This server first finds homologous structure complexes of the query using BLASTP to search the structural template database (11,263 complexes). PCFamily then searches the homologous complexes of the templates (query) from a complete genomic database (Integr8 with 6,352,363 protein sequences in 2274 species). According to these homologous complexes across multiple species, this sever infers binding models (e.g. hydrogen-bonds and conserved amino acids in the interfaces), functional modules, and t

SUBMITTER: Lo YS 

PROVIDER: S-EPMC2896147 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature