Struct2Net: a web service to predict protein-protein interactions using a structure-based approach.

ABSTRACT: Struct2Net is a web server for predicting interactions between arbitrary protein pairs using a structure-based approach. Prediction of protein-protein interactions (PPIs) is a central area of interest and successful prediction would provide leads for experiments and drug design; however, the experimental coverage of the PPI interactome remains inadequate. We believe that Struct2Net is the first community-wide resource to provide structure-based PPI predictions that go beyond homology modeling. Also, most web-resources for predicting PPIs currently rely on functional genomic data (e.g. GO annotation, gene expression, cellular localization, etc.). Our structure-based approach is independent of such methods and only requires the sequence information of the proteins being queried. The web serv

SUBMITTER: Singh R 

PROVIDER: S-EPMC2896152 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature