ConPlex: a server for the evolutionary conservation analysis of protein complex structures.

ABSTRACT: Evolutionary conservation analyses are important for the identification of protein-protein interactions. For protein complex structures, sequence conservation has been applied to determine protein oligomerization states, to characterize native interfaces from non-specific crystal contacts, and to discriminate near-native structures from docking artifacts. However, a user-friendly web-based service for evolutionary conservation analysis of protein complexes has not been available. Therefore, we developed ConPlex (http://sbi.postech.ac.kr/ConPlex/) a web application that enables evolutionary conservation analyses of protein interactions within protein quaternary structures. Users provide protein complex structures; ConPlex automatically identifies protein interfaces and carries out evolution

SUBMITTER: Choi YS 

PROVIDER: S-EPMC2896159 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature