Multi-Harmony: detecting functional specificity from sequence alignment.

ABSTRACT: Many protein families contain sub-families with functional specialization, such as binding different ligands or being involved in different protein-protein interactions. A small number of amino acids generally determine functional specificity. The identification of these residues can aid the understanding of protein function and help finding targets for experimental analysis. Here, we present multi-Harmony, an interactive web sever for detecting sub-type-specific sites in proteins starting from a multiple sequence alignment. Combining our Sequence Harmony (SH) and multi-Relief (mR) methods in one web server allows simultaneous analysis and comparison of specificity residues; furthermore, both methods have been significantly improved and extended. SH has been extended to cope with more than

SUBMITTER: Brandt BW 

PROVIDER: S-EPMC2896201 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature