Formal synthesis of salinosporamide A via NHC-catalyzed intramolecular lactonization.

ABSTRACT: An N-heterocyclic carbene (NHC) catalyzed intramolecular lactonization to prepare densely functionalized bicyclic γ-lactam-γ-lactone adducts from enals is reported. This method has been applied to the formal synthesis of salinosporamide A, a potent 20S proteasome inhibitor and anti-cancer therapeutic.

SUBMITTER: Struble JR 

PROVIDER: S-EPMC2896295 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature