Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system.

ABSTRACT:

Background

Burkholderia pseudomallei is the causative agent of melioidosis where the highest reported incidence world wide is in the Northeast of Thailand, where saline soil and water are prevalent. Moreover, recent reports indicate a potential pathogenic role for B. pseudomallei in cystic fibrosis lung disease, where an increased sodium chloride (NaCl) concentration in airway surface liquid has been proposed. These observations raise the possibility that high salinity may represent a favorable niche for B. pseudomallei. We therefore investigated the global transcriptional response of B. pseudomallei to increased salinity using microarray analysis.

Results

Transcriptome analysis of B. pseudomallei under salt stress revealed several genes significantly up-regulated in the pre

SUBMITTER: Pumirat P 

PROVIDER: S-EPMC2896371 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature