D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis.

ABSTRACT:

Objective

Several lines of evidence suggest that antipsychotic drug efficacy is mediated by dopamine type 2 (D(2)) receptor blockade. Therefore, it seems plausible that variation in the DRD(2) gene is associated with clinical response to antipsychotic drug treatment. The authors conducted the first meta-analysis to examine the relationship between DRD2 polymorphisms and antipsychotic drug response.

Method

A MEDLINE search of articles available up to December 31, 2008, yielded 18 prospective studies examining DRD2 gene variation and antipsychotic response in schizophrenia patients; of which, 10 independent studies met criteria for inclusion. Clinical response to antipsychotic treatment was defined as a 50% reduction of either the Brief Psychiatric Rating Scale total score or

SUBMITTER: Zhang JP 

PROVIDER: S-EPMC2896457 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature