Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

ABSTRACT: Improving and targeting nicotine replacement therapy (NRT) are cost-effective strategies for reducing adverse health consequences for smokers. Treatment studies document the efficacy of precessation NRT and support important roles for level of nicotine dependence and precessation smoking reduction in successful quitting. However, prior work has not identified the optimal precessation dose or means for personalizing NRT. Genome-wide association has identified groups of genomic markers associated with successful quitting, allowing us to develop a v1.0 "quit-success" genotype score. We now report influences of v1.0 quit-success genotype score, level of dependence and precessation smoking reduction in a smoking cessation trial that examined effects of 21 versus 42 mg/24 h precessation NRT. Fou

SUBMITTER: Rose JE 

PROVIDER: S-EPMC2896464 | biostudies-literature | 2010 Jul-Aug

REPOSITORIES: biostudies-literature