A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.

ABSTRACT:

Purpose

As genome-scale technologies begin to unravel the complexity of the equivalent tumors in adults, we can attempt detailed characterization of high-grade gliomas in children, that have until recently been lacking. Toward this end, we sought to validate and extend investigations of the differences between pediatric and adult tumors.

Experimental design

We carried out copy number profiling by array comparative genomic hybridization using a 32K bacterial artificial chromosome platform on 63 formalin-fixed paraffin-embedded cases of high-grade glioma arising in children and young people (<23 years).

Results

The genomic profiles of these tumors could be subclassified into four categories: those with stable genomes, which were associated with a better prognosis; those

SUBMITTER: Bax DA 

PROVIDER: S-EPMC2896553 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature