Copper-mediated N-alkynylation of carbamates, ureas, and sulfonamides. A general method for the synthesis of ynamides.

ABSTRACT: [reaction: see text] A general amination strategy for the N-alkynylation of carbamates, sulfonamides, and chiral oxazolidinones and imidazolidinones is described. A variety of substituted ynamides are available by deprotonation of amides with KHMDS followed by reaction with CuI and an alkynyl bromide.

SUBMITTER: Dunetz JR 

PROVIDER: S-EPMC2897059 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature