Regulation of multiple renin-angiotensin system genes by Sry.

ABSTRACT:

Background and objective

We demonstrated that the Sry gene complex on the spontaneously hypertensive rat (SHR) Y chromosome is a candidate locus for hypertension that accounts for the SHR Y chromosome blood pressure effect. All rat strains examined to date share six Sry loci, and a seventh Sry locus (Sry3) appears to be unique to SHR male rats. Previously, we showed that Sry1 increased activity of the tyrosine hydroxylase promoter in transfected PC12 cells, and Sry1 delivered to adrenal gland of Wistar-Kyoto (WKY) rats increased blood pressure and sympathetic nervous system activity. The objective of this study was to determine whether renin-angiotensin system genes participate in Sry-mediated effects.

Method

Sry expression vectors were co-transfected into CHO cells with luc

SUBMITTER: Milsted A 

PROVIDER: S-EPMC2897148 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature