Ontology highlight
ABSTRACT:
SUBMITTER: Vasquez V
PROVIDER: S-EPMC2897165 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Vásquez Valeria V Sotomayor Marcos M Cordero-Morales Julio J Schulten Klaus K Perozo Eduardo E
Science (New York, N.Y.) 20080801 5893
The mechanosensitive channel of small conductance (MscS) is a key determinant in the prokaryotic response to osmotic challenges. We determined the structural rearrangements associated with MscS activation in membranes, using functorial measurements, electron paramagnetic resonance spectroscopy, and computational analyses. MscS was trapped in its open conformation after the transbilayer pressure profile was modified through the asymmetric incorporation of lysophospholipids. The transition from th ...[more]