Tumor-associated macrophages and survival in classic Hodgkin's lymphoma.

ABSTRACT:

Background

Despite advances in treatments for Hodgkin's lymphoma, about 20% of patients still die from progressive disease. Current prognostic models predict the outcome of treatment with imperfect accuracy, and clinically relevant biomarkers have not been established to improve on the International Prognostic Score.

Methods

Using gene-expression profiling, we analyzed 130 frozen samples obtained from patients with classic Hodgkin's lymphoma during diagnostic lymph-node biopsy to determine which cellular signatures were correlated with treatment outcome. We confirmed our findings in an independent cohort of 166 patients, using immunohistochemical analysis.

Results

Gene-expression profiling identified a gene signature of tumor-associated macrophages that was significan

SUBMITTER: Steidl C 

PROVIDER: S-EPMC2897174 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature