Effects of snake venom proteases on human fibrinogen chains.

ABSTRACT:

Background

Proteomic approach is an effective method to study changes in human plasma proteome. Coagulopathies are commonly encountered in victims of viper envenomation which were treated with an administration of immunoglobulin. Unfortunately, this treatment shows significant risk to the patient due to an anaphylactic reaction. Since Echis carinatus Venom (EV) toxins mainly acts both directly and indirectly on fibrinogen, we planned to establish a suitable analysis of its beta (FIBB) e gamma (FIBG) chains. This study will help us to understand the mechanism of envenomation and to find alternative treatments other than the common treatment with the administration of IgG.

Study design and methods

We evaluated the EV proteolytic activity on whole human plasma proteome from the

SUBMITTER: Cortelazzo A 

PROVIDER: S-EPMC2897200 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature