Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism.

ABSTRACT: Streptococcus pyogenes is an important pathogen that causes a variety of diseases. The most common infections involve the throat (pharyngitis) or skin (impetigo); however, the factors that determine tissue tropism and severity are incompletely understood. The S. pyogenes NAD(+) glycohydrolase (SPN) is a virulence factor that has been implicated in contributing to the pathogenesis of severe infections. However, the role of SPN in determining the bacterium's tissue tropism has not been evaluated. In this report, we examine the sequences of spn and its endogenous inhibitor ifs from a worldwide collection of S. pyogenes strains. Analysis of average pairwise nucleotide diversity, average number of nucleotide differences, and ratio of nonsynonymous to synonymous substitutions revealed significan

SUBMITTER: Riddle DJ 

PROVIDER: S-EPMC2897333 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature