Identification of multiple substrates of the StkP Ser/Thr protein kinase in Streptococcus pneumoniae.

ABSTRACT: Monitoring the external environment and responding to its changes are essential for the survival of all living organisms. The transmission of extracellular signals in prokaryotes is mediated mainly by two-component systems. In addition, genomic analyses have revealed that many bacteria contain eukaryotic-type Ser/Thr protein kinases. The human pathogen Streptococcus pneumoniae encodes 13 two-component systems and has a single copy of a eukaryotic-like Ser/Thr protein kinase gene designated stkP. Previous studies demonstrated the pleiotropic role of the transmembrane protein kinase StkP in pneumococcal physiology. StkP regulates virulence, competence, and stress resistance and plays a role in the regulation of gene expression. To determine the intracellular signaling pathways controlled by

SUBMITTER: Novakova L 

PROVIDER: S-EPMC2897338 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature