The Pseudomonas aeruginosa pathogenicity island PAPI-1 is transferred via a novel type IV pilus.

ABSTRACT: Pseudomonas aeruginosa is a major cause of nosocomial infections, particularly in immunocompromised patients or in individuals with cystic fibrosis. The notable ability of P. aeruginosa to inhabit a broad range of environments, including humans, is in part due to its large and diverse genomic repertoire. The genomes of most strains contain a significant number of large and small genomic islands, including those carrying virulence determinants (pathogenicity islands). The pathogenicity island PAPI-1 of strain PA14 is a cluster of 115 genes, and some have been shown to be responsible for virulence phenotypes in a number of infection models. We have previously demonstrated that PAPI-1 can be transferred to other P. aeruginosa strains following excision from the chromosome of the donor. Here w

SUBMITTER: Carter MQ 

PROVIDER: S-EPMC2897670 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature