Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus.

ABSTRACT:

Background

Aspergillus fumigatus (A. fumigatus) is a ubiquitous fungus which reproduces asexually by releasing abundant airborne conidia (spores), which are easily respirable. In allergic and immunocompromised individuals A. fumigatus can cause a wide spectrum of diseases, including allergic bronchopulmonary aspergillosis, aspergilloma and invasive aspergillosis. Previous studies have demonstrated that A. fumigatus conidia are internalized by macrophages and lung epithelial cells; however the exact transcriptional responses of airway epithelial cells to conidia are currently unknown. Thus, the aim of this study was to determine the transcriptomic response of the human bronchial epithelial cell line (16HBE14o-) following interaction with A. fumigatus conidia. We used fluorescence-ac

SUBMITTER: Gomez P 

PROVIDER: S-EPMC2897809 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature