Genetics of susceptibility to infection with enteric pathogens.

ABSTRACT:

Purpose of review

This review examines recent developments in human genetic susceptibility to enteropathogens that cause infectious diarrhea.

Recent findings

The affinity of specific norovirus genogroups to different histoblood group antigens (HBGAs) on secretor cells has been studied in different epidemiologic studies. HBGAs are also used as receptors by Vibrio cholerae with different degrees of affinity between biotypes. Polymorphisms in the CD14, lactoferrin and osteoprotegerin promoter genes were associated to diarrhea in travelers. Single nucleotide polymorphisms in the IL-8 genes are also associated to increased risk for enteroaggregative Escherichia coli and Clostridium difficile infection. IL-10 haplotypes were associated to enterotoxigenic E. coli associated diarrhe

SUBMITTER: Flores J 

PROVIDER: S-EPMC2897815 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature