Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.

ABSTRACT:

Background

Most of the genetic variants identified from genome-wide association studies of breast cancer have not been validated in Asian women. No risk assessment model that incorporates both genetic and clinical predictors is currently available to predict breast cancer risk in this population.

Methods

We analyzed 12 single-nucleotide polymorphisms (SNPs) identified in recent genome-wide association studies mostly of women of European ancestry as being associated with the risk of breast cancer in 3039 case patients and 3082 control subjects who participated in the Shanghai Breast Cancer Study. All participants were interviewed in person to obtain information regarding known and suspected risk factors for breast cancer. The c statistic, a measure of discrimination ability w

SUBMITTER: Zheng W 

PROVIDER: S-EPMC2897876 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature