Factor V Leiden mutation and thromboembolism risk in women receiving adjuvant tamoxifen for breast cancer.

ABSTRACT:

Background

Tamoxifen use has been associated with increased risk of thromboembolic events (TEs) in women with breast cancer and women at high risk for the disease. Factor V Leiden (FVL) is the most common inherited clotting factor mutation and also confers increased thrombosis risk. We investigated whether FVL was associated with TE risk in women with early-stage breast cancer who took adjuvant tamoxifen.

Methods

A case-control study was conducted among 34 Cancer and Leukemia Group B (CALGB) institutions. We matched each of 124 women who had experienced a documented TE while taking adjuvant tamoxifen for breast cancer (but who were not necessarily on a CALGB treatment trial) to two control subjects (women who took adjuvant tamoxifen but did not experience TE) by age at diagn

SUBMITTER: Garber JE 

PROVIDER: S-EPMC2897879 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature