A human functional protein interaction network and its application to cancer data analysis.

ABSTRACT:

Background

One challenge facing biologists is to tease out useful information from massive data sets for further analysis. A pathway-based analysis may shed light by projecting candidate genes onto protein functional relationship networks. We are building such a pathway-based analysis system.

Results

We have constructed a protein functional interaction network by extending curated pathways with non-curated sources of information, including protein-protein interactions, gene coexpression, protein domain interaction, Gene Ontology (GO) annotations and text-mined protein interactions, which cover close to 50% of the human proteome. By applying this network to two glioblastoma multiforme (GBM) data sets and projecting cancer candidate genes onto the network, we found that the ma

SUBMITTER: Wu G 

PROVIDER: S-EPMC2898064 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature