Ontology highlight
ABSTRACT:
SUBMITTER: Pene-Dumitrescu T
PROVIDER: S-EPMC2898387 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Pene-Dumitrescu Teodora T Smithgall Thomas E TE
The Journal of biological chemistry 20100507 28
The Bcr-Abl kinase inhibitor imatinib is remarkably effective in chronic myelogenous leukemia (CML), although drug resistance is an emerging problem. Myeloid Src family kinases such as Hck and Lyn are often overexpressed in imatinib-resistant CML cells that lack Bcr-Abl mutations. Here we tested whether Hck overexpression is sufficient to induce imatinib resistance using both wild-type Hck and a mutant (Hck-T338A) that is uniquely sensitive to the pyrazolo-pyrimidine inhibitor, NaPP1. Expression ...[more]