Ontology highlight
ABSTRACT:
SUBMITTER: Halterman MW
PROVIDER: S-EPMC2898390 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Halterman Marc W MW Gill Molly M DeJesus Chris C Ogihara Mitsunori M Schor Nina F NF Federoff Howard J HJ
The Journal of biological chemistry 20100506 28
Hypoxia-induced gene expression is a critical determinant of neuron survival after stroke. Understanding the cell autonomous genetic program controlling adaptive and pathological transcription could have important therapeutic implications. To identify the factors that modulate delayed neuronal apoptosis after hypoxic injury, we developed an in vitro culture model that recapitulates these divergent responses and characterized the sequence of gene expression changes using microarrays. Hypoxia indu ...[more]