Genome-wide survey of microRNA-transcription factor feed-forward regulatory circuits in human.

ABSTRACT: In this work, we describe a computational framework for the genome-wide identification and characterization of mixed transcriptional/post-transcriptional regulatory circuits in humans. We concentrated in particular on feed-forward loops (FFL), in which a master transcription factor regulates a microRNA, and together with it, a set of joint target protein coding genes. The circuits were assembled with a two step procedure. We first constructed separately the transcriptional and post-transcriptional components of the human regulatory network by looking for conserved over-represented motifs in human and mouse promoters, and 3'-UTRs. Then, we combined the two subnetworks looking for mixed feed-forward regulatory interactions, finding a total of 638 putative (merged) FFLs. In order to investiga

SUBMITTER: Re A 

PROVIDER: S-EPMC2898627 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature