Prospects for proteomics Directed Genomic and Genetic Analyses in Disease Discoveries.

ABSTRACT: Proteomic discoveries are usually made using database searches for identification of proteins in a given protein sample derived from cells or tissues. High throughput searches leave a number of peptides not analyzed for a variety of reasons, such as posttranslational modification or a mutation that results changes in the peptide that is not present in databases. Such mutations may be critically important in causing disease conditions. Accounts from ocular diseases are presented where the search provided results often from non-conventional databases (such as structural database instead of protein database) due to the presence of information about a mutant peptide. We contemplate that better algorithms and the ability to determine probabilities of different amino acids in the available seque

SUBMITTER: Bhattacharya SK 

PROVIDER: S-EPMC2899679 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature