Plasma Protein Biomarkers Correlated with the Development of Diet-Induced Type 2 Diabetes in Mice.

ABSTRACT: INTRODUCTION: Early detection, assessment of disease progression, and application of an appropriate therapeutic intervention are all important for the care of patients with type 2 diabetes. Currently, however, there is no simple test for early detection of type 2 diabetes. Established diagnostic tests for the disease including oral glucose tolerance, fasting blood glucose, and hemoglobin A1c are relatively late markers where the disease has already progressed. Since blood is in direct contact with many tissues, we hypothesized that pathological tissue changes are likely to be reflected in proteomic profiles of plasma. METHODS: Mice were reared either on regular chow or a high-fat diet at weaning and several physiological responses (i.e., weight, fasting plasma glucose and insulin, and gluc

SUBMITTER: Okada S 

PROVIDER: S-EPMC2899708 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature