Long-term modulations in the vertebral transcriptome of adolescent-stage rats exposed to binge alcohol.

ABSTRACT:

Aims

Dangerous alcohol consumption practices are common in adolescents, yet little is known about their consequences on attainment of peak bone mass and long-term skeletal integrity. We previously demonstrated that binge alcohol-exposed adolescent rats showed site-specific reductions in accruement of bone mineral density and bone strength, which were incompletely recovered following prolonged alcohol abstinence. Currently, we analysed the vertebral transcriptome of adolescent rats following alcohol treatment and abstinence to identify long-term molecular changes in the lumbar spine.

Methods

Sixty male adolescent Sprague-Dawley rats were assigned to one of six treatment groups receiving binge alcohol (3 g/kg) or saline i.p., 3 consecutive days (acute binge), 4 consecutive wee

SUBMITTER: Callaci JJ 

PROVIDER: S-EPMC2899847 | biostudies-literature | 2010 Jul-Aug

REPOSITORIES: biostudies-literature