Transcriptome analysis of monocyte-HIV interactions.

ABSTRACT:

Background

During HIV infection and/or antiretroviral therapy (ART), monocytes and macrophages exhibit a wide range of dysfunctions which contribute significantly to HIV pathogenesis and therapy-associated complications. Nevertheless, the molecular components which contribute to these dysfunctions remain elusive. We therefore applied a parallel approach of genome-wide microarray analysis and focused gene expression profiling on monocytes from patients in different stages of HIV infection and/or ART to further characterise these dysfunctions.

Results

Processes involved in apoptosis, cell cycle, lipid metabolism, proteasome function, protein trafficking and transcriptional regulation were identified as areas of monocyte dysfunction during HIV infection. Individual genes potent

SUBMITTER: Van den Bergh R 

PROVIDER: S-EPMC2900222 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature