Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review.

ABSTRACT:

Background

Pernicious anaemia is undeniably associated with vitamin B12 deficiency, but the association between subnormal vitamin B12 concentrations and anaemia in older people is unclear. The aim of this systematic review was to evaluate the association between subnormal vitamin B12 concentrations and anaemia in older people.

Methods

Clinical queries for aetiology and treatment in bibliographic databases (PubMed [01/1949-10/2009]; EMBASE [01/1980-10/2009]) were used. Reference lists were checked for additional relevant studies. Observational studies (> or =50 participants) and randomized placebo-controlled intervention trials (RCTs) were considered.

Results

25 studies met the inclusion criteria. Twenty-one observational cross-sectional studies (total number of partic

SUBMITTER: den Elzen WP 

PROVIDER: S-EPMC2900261 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature