Transcriptional regulation of gene expression clusters in motor neurons following spinal cord injury.

ABSTRACT:

Background

Spinal cord injury leads to neurological dysfunctions affecting the motor, sensory as well as the autonomic systems. Increased excitability of motor neurons has been implicated in injury-induced spasticity, where the reappearance of self-sustained plateau potentials in the absence of modulatory inputs from the brain correlates with the development of spasticity.

Results

Here we examine the dynamic transcriptional response of motor neurons to spinal cord injury as it evolves over time to unravel common gene expression patterns and their underlying regulatory mechanisms. For this we use a rat-tail-model with complete spinal cord transection causing injury-induced spasticity, where gene expression profiles are obtained from labeled motor neurons extracted with laser

SUBMITTER: Ryge J 

PROVIDER: S-EPMC2900267 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature