Evidence for an early evolutionary emergence of gamma-type carbonic anhydrases as components of mitochondrial respiratory complex I.

ABSTRACT:

Background

The complexity of mitochondrial complex I (CI; NADH:ubiquinone oxidoreductase) has increased considerably relative to the homologous complex in bacteria. Comparative analyses of CI composition in animals, fungi and land plants/green algae suggest that novel components of mitochondrial CI include a set of 18 proteins common to all eukaryotes and a variable number of lineage-specific subunits. In plants and green algae, several purportedly plant-specific proteins homologous to gamma-type carbonic anhydrases (gammaCA) have been identified as components of CI. However, relatively little is known about CI composition in the unicellular protists, the characterizations of which are essential to our understanding of CI evolution.

Results

We have performed a tandem mass sp

SUBMITTER: Gawryluk RM 

PROVIDER: S-EPMC2900272 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature