Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer.

ABSTRACT:

Unlabelled

Leukoplakia is the most common premalignant lesion of the oral cavity. Epidermal growth factor receptor (EGFR) abnormalities are associated with oral tumorigenesis and progression. We hypothesized that EGFR expression and gene copy number changes are predictors of the risk of an oral premalignant lesion (OPL) progressing to oral squamous cell carcinoma (OSCC). A formalin-fixed, paraffin-embedded OPL biopsy specimen was collected from each of 162 patients in a randomized controlled clinical trial. We assessed EGFR expression by immunohistochemistry with two

Methods

a semiquantitative analysis (145 evaluable specimens) and an automated quantitative analysis (127 evaluable specimens). EGFR gene copy number was assessed by fluorescence in situ hybridization (FISH) in

SUBMITTER: Taoudi Benchekroun M 

PROVIDER: S-EPMC2900459 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature