Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients.

ABSTRACT:

Purpose

Selective digestive microbial decontamination (SDD) is hypothesized to benefit patients in intensive care (ICU) by suppressing Gram-negative potential pathogens from the colon without affecting the anaerobic intestinal microbiota. The purpose of this study was to provide more insight to the effects of digestive tract and oropharyngeal decontamination on the intestinal microbiota by means of a prospective clinical trial in which faecal samples were collected from ICU patients for intestinal microbiota analysis.

Methods

The faecal samples were collected from ICU patients enrolled in a multicentre trial to study the outcome of SDD and selective oral decontamination (SOD) in comparison with standard care (SC). Fluorescent in situ hybridization (FISH) was used to analyze

SUBMITTER: Benus RF 

PROVIDER: S-EPMC2900589 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature