The key feature for early migratory processes: Dependence of adhesion, actin bundles, force generation and transmission on filopodia.

ABSTRACT: Migration of cells is one of the most essential prerequisites to form higher organisms and depends on a strongly coordinated sequence of processes. Early migratory events include substrate sensing, adhesion formation, actin bundle assembly and force generation. While substrate sensing was ascribed to filopodia, all other processes were believed to depend mainly on lamellipodia of migrating cells. In this work we show for motile keratinocytes that all processes from substrate sensing to force generation strongly depend on filopodial focal complexes as well as on filopodial actin bundles. In a coordinated step by step process, filopodial focal complexes have to be tightly adhered to the substrate and to filopodial actin bundles to enlarge upon lamellipodial contact forming classical focal ad

SUBMITTER: Schafer C 

PROVIDER: S-EPMC2900617 | biostudies-literature | 2010 Apr-Jun

REPOSITORIES: biostudies-literature