Structure elucidation of dimeric transmembrane domains of bitopic proteins.

ABSTRACT: The interaction between transmembrane helices is of great interest because it directly determines biological activity of a membrane protein. Either destroying or enhancing such interactions can result in many diseases related to dysfunction of different tissues in human body. One much studied form of membrane proteins known as bitopic protein is a dimer containing two membrane-spanning helices associating laterally. Establishing structure-function relationship as well as rational design of new types of drugs targeting membrane proteins requires precise structural information about this class of objects. At present time, to investigate spatial structure and internal dynamics of such transmembrane helical dimers, several strategies were developed based mainly on a combination of NMR spectros

SUBMITTER: Bocharov EV 

PROVIDER: S-EPMC2900626 | biostudies-literature | 2010 Apr-Jun

REPOSITORIES: biostudies-literature