BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells.

ABSTRACT: BCL6 encodes a transcriptional repressor that is essential for the germinal center (GC) reaction and important in lymphomagenesis. Although its promoter has been well studied, little is known concerning its possible regulation by more distal elements. To gain such information, we mapped critical histone modifications associated with active transcription within BCL6 as well as far upstream sequences at nucleosomal resolution in B-cell lines and in normal naive and GC B cells. Promoter-associated and intronic CpG islands (CGIs) in BCL6 showed a reciprocal pattern of histone modifications. Gene expression correlated with a paradoxical loss from the intronic CGI of histone H3 lysine-4 trimethylation, normally associated with transcription, suggesting that the intronic CGI may interfere with tr

SUBMITTER: Ramachandrareddy H 

PROVIDER: S-EPMC2900701 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature