Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh AC
PROVIDER: S-EPMC2901095 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Hsieh Andrew C AC Costa Maria M Zollo Ornella O Davis Cole C Feldman Morris E ME Testa Joseph R JR Meyuhas Oded O Shokat Kevan M KM Ruggero Davide D
Cancer cell 20100301 3
We genetically dissect the contribution of the most prominent downstream translational components of mTOR signaling toward Akt-driven lymphomagenesis. While phosphorylation of rpS6 is dispensable for cancer formation, 4EBP-eIF4E exerts significant control over cap-dependent translation, cell growth, cancer initiation, and progression. This effect is mediated at least in part through 4EBP-dependent control of Mcl-1 expression, a key antiapoptotic protein. By using an active site inhibitor of mTOR ...[more]