Composite functional module inference: detecting cooperation between transcriptional regulation and protein interaction by mantel test.

ABSTRACT:

Background

Functional modules are basic units of cell function, and exploring them is important for understanding the organization, regulation and execution of cell processes. Functional modules in single biological networks (e.g., the protein-protein interaction network), have been the focus of recent studies. Functional modules in the integrated network are composite functional modules, which imply the complex relationships involving multiple biological interaction types, and detect them will help us understand the complexity of cell processes.

Results

We aimed to detect composite functional modules containing co-transcriptional regulation interaction, and protein-protein interaction, in our pre-constructed integrated network of Saccharomyces cerevisiae. We computationally

SUBMITTER: Wu C 

PROVIDER: S-EPMC2901225 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature