Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients.

ABSTRACT:

Background

Circulating CD34+ progenitor cells have the potential to differentiate into a variety of cells, including endothelial cells. Knowledge is still scarce about the transcriptional programs used by CD34+ cells from peripheral blood, and how these are affected in coronary artery disease (CAD) patients.

Results

We performed a whole genome transcriptome analysis of CD34+ cells, CD4+ T cells, CD14+ monocytes, and macrophages from 12 patients with CAD and 11 matched controls. CD34+ cells, compared to other mononuclear cells from the same individuals, showed high levels of KRAB box transcription factors, known to be involved in gene silencing. This correlated with high expression levels in CD34+ cells for the progenitor markers HOXA5 and HOXA9, which are known to control ex

SUBMITTER: van der Pouw Kraan TC 

PROVIDER: S-EPMC2901320 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature