A total synthesis of norhalichondrin B.

ABSTRACT: Four corners: The syntheses of four key building blocks for the total synthesis of norhalichondrin B (see structure) are described. The assembly of these subunits into the natural product is also reported. Key features of the synthesis are the use of the Achmatowicz oxidation/ionic hydrogenation for the synthesis of pyrans and pyranopyrans, and the application of tandem metathesis for the synthesis of pyranopyrans.

SUBMITTER: Jackson KL 

PROVIDER: S-EPMC2901598 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature