The immunohistochemistry of invasive and proliferative phenotype switching in melanoma: a case report.

ABSTRACT: To date there is no effective therapy for metastatic melanoma and at the molecular level the disease progression is poorly understood. A recent study by our group led to the development of a novel phenotype switching model for melanoma progression, wherein cells transition back-and-forth between states of proliferation and invasion to drive disease progression. To explore the model's clinical relevance we interrogated phenotype-specific expression patterns in human melanoma patient material. A matched primary/metastasis pair from a human melanoma patient was obtained and immunohistochemically stained for proliferative and invasive phenotype markers. These were also stained for hypoxia and blood vessel markers. Proliferative phenotype markers Melan-A and Mitf showed consistent anti-correlat

SUBMITTER: Eichhoff OM 

PROVIDER: S-EPMC2901773 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature