A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition.

ABSTRACT:

Objective

There are significant individual differences in the extent to which mood and cognition change as a function of reproductive stage, menstrual phase, postpartum, and hormone therapy use. This review explores the extent to which variations or polymorphisms in the estrogen receptor alpha gene (ESR1) predict cognitive and mood outcomes.

Methods

A literature search was conducted from 1995 to November 2009 through PubMed, Embase, and PsychINFO. Twenty-five manuscripts that summarize investigations of ESR1 in mental health were reviewed.

Results

Among studies investigating ESR1 in relation to cognition, 11 of 14 case-control studies reported an association between ESR1 polymorphisms and risk for developing dementia. Three of four prospective cohort studies reported

SUBMITTER: Sundermann EE 

PROVIDER: S-EPMC2901885 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature